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Patent literature is an important source of technological information.A comparative analysis of patents of military medical research institutions of the US Armed Forces in THOMSON INNOVATION patent database could reveal their research achievements and development,and provide inspiration and reference for the innovation and development of our military medical science.
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To improve the science principle of input-output evaluation in medical research institutions,this study uses literature research and expert interviews to make a comparison between domestic and foreign evaluation criterion.There are several problems about input-output evaluation in medical research institutions in China,such as less flexibility and targeted methods,inappropriate models,inadequate indicators and quantitative metrics.Seveal combinations of elements should be considered for input-output evaluation in medical research institutions,which is parallels and distinctions,qualitative and quantitative methods,quality and quantity,process and results,focus and full,and also emphasis on the application of information technology.
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Objective To analyze the characteristics of contributions and the reasons why Chinese authors engaged in scientific research favor to contribute their papers to PLoS One by comparing the papers published in PLoS One and its series by authors from China and other countries.Methods Papers published in PLoS One by Chinese au-thors engaged in scientific research were retrieved from Web of Science by setting the retrieval parameters and ana-lyzed.Results The number of papers published in PLoS One series by authors from China increased rapidly.The number of papers published in PLoS One was significantly larger than that published in other PLoS One series. Conclusion The scientific research scale is unceasingly expanded.Why the Chinese authors engaged in scientific research favor to contribute their papers to PLoS One are due to its attractive power and the guidance of scientific and technological evaluation management in China.
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Currently, monitoring system of awareness of the depth of anesthesia has been more and more widely used in clinical practices. The intelligent evaluation algorithm is the key technology of this type of equipment. On the basis of studies about changes of electroencephalography (EEG) features during anesthesia, a discussion about how to select reasonable EEG parameters and classification algorithm to monitor the depth of anesthesia has taken place. A scheme which combines time domain analysis, frequency domain analysis and the variability of EEG and decision tree as classifier and least squares to compute Depth of anesthesia Index (DOAI) is proposed in this paper. Using the EEG of 40 patients who underwent general anesthesia with propofol, and the classification and the score of the EEG annotated by anesthesiologist, we verified this scheme with experiments. Classification and scoring was based on a combination of modified observer assessment of alertness/sedation (MOAA/S), and the changes of EEG parameters of patients during anesthesia. Then we used the BIS index to testify the validation of the DOAI. Results showed that Pearson's correlation coefficient between the DOAI and the BIS over the test set was 0.89. It is demonstrated that the method is feasible and has good accuracy.
Subject(s)
Humans , Algorithms , Anesthesia, General , Decision Trees , Electroencephalography , Entropy , Intraoperative Awareness , Monitoring, Physiologic , PropofolABSTRACT
Cold Spring Harbor Laboratory began its doctoral program in 1999, but its training model is very distinctive and has been emulated by many institutes. Its features are mainly embodied in the following aspects:the aim of cultivating outstanding talent, the idea of lifelong learning, the system of“two-tier”mentoring program, the security measure of tuition paid in full by the school and the free and open environment. To learn from those advanced training experience, great efforts should be made in our doctoral cultivation mode in the aspects of enrollment system, education resources allocation method, and the training objective and emphasis.
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Translational medicine is a more effective and efficient way to improve the investment return on bioscience and provide equitable access to high—quality healthcare.Recognizing the need for a new impetus to spur clinical and translational research,the National Institutes of Health established the Clinical and Translational Science Awards Program.
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Biodefense research based on modern information technology is an important supplement to traditional biode -fense capacity building and an important part of the national biodefense system in the 21st century.This article outlines the typical biodefense information systems developed in the last ten years and analyzes the development trends of this research field.It is hoped that more domestic research institutions or researchers can become interested in this field .
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Objective To investigate the expression and significance of ?-endorphin in hippocampus after high power microwave (HPM) radiation. Methods 50 male Wistar rats were sacrificed at 6h, 1d, 3d, 7d, 14d, 28 days after exposure to 12mW/cm~2 HPM imitational source radiation. The hippocampus was harvested, the characteristics of injury to the hippocampus and expression of ?-endorphin were evaluated by means of light microscope, EM, immunohistochemistry and image analysis. Results In the neutrons of hippocampus, mitochondrial swelling and myelin sheath confluence and dissociation were observed 6 hours after radiation, and mitochondrial swelling, cavitation, disruption of crista, concentration margining of chromatin, blurring of synaptic cleft, piling or evacuation of vesicles were observed 3 days after HPM radiation. The expression of ?-endorphin in cytoplasm of neurons was up-regulated continuously from 1 to 7 days, peaking at 7 days, restoring to normal level from 14 to 28 days after radiation. Conclusion HPM can produce injury to the hippocampus at histological and ultrastructural levels. The expression of ?-endorphin is up-regulated, and it might play an important role in the pathophysiological process of injury and repair in the hippocampus.